Endocrine Abstracts

Introduction: Pheochromocytoma is one of the major secondary causes of hypertension. The classic triad of pheochromocytoma symptoms of headache, sweating and tachycardia is not present in a high percentage of patients and is sometimes diagnosed as incidentaloma or atypical presentations.Case report: The authors present a 56-year-old man, with no known diseases, referred to Endocrinology evaluation by incidentaloma of the right adrenal gland, from the Pne...

Introduction: Secondary causes of diabetes refer to a category in which diabetes is associated with other diseases. They are thought to constitute less than 2% of the total cases of diabetes.Case report: A 56 year-old caucasian man, with no relevant medical history, presented to the Emergency Department with fatigue, polyuria, polydipsia, polyphagia and involuntary weight loss (6 kg in two weeks). He was hemodynamically stable and exhibited a glycaemia o...

Introduction: The endocrine system is often affected in the course of HIV infection. However, hypopituitarism and diabetes insipidus are uncommon disorders in these patients and have been related to drugs, infections of the central nervous system and neoplastic infiltration, in extremely rare cases.Case report: We present a case of a 42-year-old man with HIV infection known since 2005, but undergoing antiretroviral therapy only since 2010 (emtricitabine/...

Introduction: Bilateral macronodular adrenal hyperplasia is a rare cause of Cushing’s syndrome (CS) characterized by multiple adrenal nodules >1 cm. It can be diagnosed in patients with overt CS but is more often diagnosed incidentally, especially in the 5th or 6th decades of life.Clinical case: 61-year-old woman with type 2 diabetes, arterial hypertension and dyslipidemia treated with metformin+sitagliptin 1000/50 mg bid, valsartan+hydrochlorot...

Background: Diabetes is an important risk factor for major adverse cardiovascular events (MACE). Although the increased risk for MACE is well known, the impact on the in-hospital outcomes remains incompletely understood. Our aim was to evaluate the interrelation between diabetes and MACE in a central hospital in the North of Portugal between 2009 and 2015.Methods: We evaluated retrospectively the hospitalizations due to MACE including stroke or transient...

Introduction: Pheochromocytomas/paragangliomas are rare neuroendocrine tumors. Although mostly sporadic, about 1/3 of the cases correspond to inherited autosomal dominant syndromes, often associated with germline mutations of the SDHD, SDHC and SDHB genes. The association with the SDHAF2(SDH5) gene has been recently discovered, with only few cases published worldwide, and it presents as a paraganglioma of the head and neck, without previous known description of other locations...

Introduction: Given the significant impact of thyroid function on body weight, energy metabolism and adipocytes physiology, our aim was to study the impact of subclinical thyroid dysfunction in plasmatic levels of adipokines and ICAM-1 (intercellular adhesion molecule 1).Methods: We evaluated 98 patients with autoimmune thyroid disease divided into three groups: 30 who were euthyroid (TSH=0.35–4.94 UI/ml), 35 with subclinical hypothyroidism (hypoSC,...

Introduction: Graves’ disease is an autoimmune disease accounting for the majority of hyperthyroidism cases.Aim: We aimed to assess the interrelationships between cardiovascular risk factors, autoimmunity, insulin resistance and treatment in Graves’ disease.Material and methods: We measured free T3 (FT3), free T4 (FT4), TSH, thyrotropin receptor antibodies (TRAb), anti-thyroglobulin and anti-TPO antibodies, thyro...

Introduction: Thyroid dysfunction has been associated with cardiovascular events since it worsens atherogenesis, insulin resistance and dyslipidemia. Thyroid hormones and adipokines interact with each other to regulate metabolism. The impact of thyroid dysfunction on adipokines serum levels remains controversial.Objective: To evaluate the interrelations between thyroid function and cardiovascular risk factors as insulin resistance, lipid profile, inflamm...

Introduction: The interrelationship between autoimmune thyroiditis, Graves’ disease and plasma adipokines levels remains elusive.Aims: We aimed to compare the levels of adiponectin, resistin and PAI-1 levels in patients with autoimmune thyroiditis and Graves’ disease.Subjects and methods: We recorded thyroid function tests, BMI, the levels of total cholesterol (TC), HDL, LDL-cholesterol, triglycerides (TG), apolipoprotein...